Introducing new Eloctate (one-stage) Population PK models on WAPPS-Hemo.

Two new models (Model 1: using fat-free mass and age information; Model 2: using fat-free mass, age and blood group information) were developed in order to expand the previous Eloctate models along the age continuum.

The new models incorporate data from 1,343 patients of which the vast majority was taken from the WAPPS-Hemo database that collects real-world infusions from all over the globe. The new models were derived on patients aged 1 to 92 years and are appropriate for use in estimating individual PK estimates on the WAPPS-Hemo platform. The precision on half-life estimates where three factor concentrate plasma measurements are provided is very high (see figure).

One of the key goals of WAPPS-Hemo is to collect enough PK data that will allow us to build factor concentrate models with the highest precision possible and that are valid for the greatest number of patients. Thank you to all of the Hemophilia Treatment Centres who are contributing to this goal!